NaPDI

Center of Excellence for Natural Drug Interaction Research (NaPDI)

NCCIH/NIH-funded | Research Associate

In fall 2015 the National Institutes of Health, National Center for Complementary and Integrative Health created a Natural Product-Drug Interaction (NaPDI) Center of Excellence to address the lack of consistency in design, implementation, and documentation of studies to assess clinical relevance of natural product-drug interactions. The goal of the center is to provide leadership in the study of natural product-drug interactions, with the ultimate goal of developing a definitive approach to determining the clinical relevance of pharmacokinetic interactions between natural products and conventional medications. Dean Bruce Pinkleton and Clinical Associate Professor Rebecca Cooney represent Murrow College on the five-year grant as part of a collaboration between the University of Washington College of Pharmacy, WSU College of Pharmacy, the University of North Carolina at Greensboro, and University of Pittsburgh. As part of the Informatics Core, Pinkleton and Cooney are responsible for the planning, design, creation, and evaluation metrics of the public portal that provide access to the organized raw data housed in a repository. The grant is $10.5m (2015-2020).


Public Portal

napdi.org

Brand Platform

Visual Identity

NaPDI logo

NaPDI brand stylesheet

Our Goals

  1. Develop Recommended Approaches to guide researchers in the proper conduct of natural product-drug interaction studies, which will evolve over time concurrent with emerging technologies and new research data; and
  2. Apply the Recommended Approaches in evaluating selected model natural products as precipitants of interactions with clinically relevant object drugs.

Core Messaging

Our Mission

Create a Center of Excellence that will provide leadership in the study of natural product-drug interactions, with the ultimate goal of developing a definitive approach to determine the clinical relevance of pharmacokinetic interactions between natural products (NPs) and conventional medications.

Value Statement

The National Institutes of Health, National Center for Complementary and Integrative Health has created a Natural Product-Drug Interaction (NaPDI) Center of Excellence to address the lack of consistency in design, implementation, and documentation of studies to assess clinical relevance of natural product-drug interactions.

Our Objectives

  • Work Collaboratively with NCCIH to identify, prioritize, and source 4-6 NPs as potential precipitants of clinically meaningful interactions with commonly used medications.
  • Develop a Statement of Work or administrative supplement for each of the selected NPs to address existing gaps in the scientific literature and provide a definitive assessment about the clinical relevance of any pharmacokinetic interaction.
  • Develop and maintain a repository and public access portal for the data and resources generated that will lead to improved design of future research.
  • Establish a set of Recommended Approaches to address the unique challenges related to the study of NP-drug interactions.

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